נייע באריכט די לעצטע טעג איבער CBD פאר Seizures
Can CBD Help Seizures?
CBD is a compound found in the cannabis sativa plant and does not include significant amounts (less than 0.3%) of delta-9 tetrahydrocannabinol (THC), which is the psychoactive constituent of cannabis known to cause intoxication.
CBD has been shown to act on the brain’s G protein-coupled receptor 55 (GPR55)—the part of the brain that decreases the release of calcium into cells, thereby decreasing excitatory currents and leading to seizure activity. Through clinical studies, it has been determined that CBD can help reduce neuron excitability.
Can CBD Help Prevent Seizures?
“CBD is an effective treatment for seizures and epilepsy,” says Dr. Gardner. “It has been shown in studies to be similarly effective to other anti-epileptic medications that we commonly use,” she says. “However, it may not work for every type of seizure or all epilepsy patients. For some patients it leads to full seizure control, other patients have a reduction in seizure frequency and others have no improvement at all.”
For patients with epilepsy, CBD is shown to control their seizures and prevent breakthrough seizures from happening. However, CBD does not treat or cure the underlying cause of the epilepsy, and responses vary from person to person, Dr. Gardner adds.
“Data showed that there was approximately 40% reduction in the median seizure count compared to baseline, and over 50% of patients saw at least a 50% reduction in seizures,” says Dr. Patel.
FDA-Approved CBD for Seizures
Studies in the past five years have evaluated a mostly purified plant-based version of CBD in the treatment of different types of epilepsy such as Lennox Gastaut syndrome (LGS) and Dravet syndrome, says Dr. Patel. These studies lead to the development of Epidiolex, the first FDA-approved prescription CBD used to treat seizures associated with these syndromes in patients two years and older.
Epidiolex is closely regulated and monitored to ensure that the product is pure CBD, according to Dr. Gardner. It’s proven to be an efficacious treatment for epilepsy, especially in patients with treatment-resistant epilepsy, (such as Dravet Syndrome or LGS). This is the safest form of CBD to take on a daily basis for seizure control, since it doesn’t contain THC. Epidiolex also allows medical professionals to treat patients at higher doses, as high-dose CBD is proven to be safe, whereas the effects of higher amounts of THC taken on a daily basis (especially in a developing brain) require more research.
“It is important that a patient with epilepsy be treated with a product that is high in CBD and as low as possible in THC (in other words a high CBD to THC ratio),” says Dr. Gardner.
https://www.forbes.com/health/cbd/cbd-for-seizures/
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